What is PEP? Is it different than PrEP?

Post-Exposure Prophylaxis (PEP)

Photo of a patient examining medication with doctor

PEP is the use of antiretroviral drugs after a single high-risk event to stop HIV seroconversion. PEP must be started as soon as possible to be effective—and always within 72 hours of a possible exposure.

Resources for Consumers

Basic PEP Q&As – learn the basics about PEP and if it’s right for you.

PEP 101 Consumer Info Sheet (English and Spanish) pdf icon[PDF – 706 KB]

PrEP vs PEP

What’s-the-Difference-Between-PrEP-and-P

What is the difference between PrEP and PEP?

Pre-exposure prophylaxis is also known as PrEP. It is an HIV prevention medication in which HIV-negative people take an oral pill once a day before coming into contact with HIV. This helps to reduce their risk of HIV infection. The drug must be taken for at least 7 days to reach optimal levels of protection against HIV.

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This contrasts post-exposure prophylaxis also known as PEP. PEP is an HIV prevention strategy in which HIV-negative people take anti-HIV medications after coming into contact with HIV to reduce their risk of HIV infection. PEP must be started within 72 hours after HIV exposure.

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To learn more about PrEP, check out:

https://www.hiv.gov/hiv-basics/hiv-prevention/using-hiv-medication-to-reduce-risk/pre-exposure-prophylaxis

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To learn more about PEP, check out these sites:

https://www.hiv.gov/hiv-basics/hiv-prevention/using-hiv-medication-to-reduce-risk/post-exposure-prophylaxis